Biomechanics & Mechanobiology Laboratory

Principal Investigator: Dr. Scott Wood

Journal Publications

12. Saraswat R*, Ratnayake I*, Perez EC, Schutz, WM, Zhu Z, Ahrenkiel SP, Wood ST. CellWell: A micropatterned biphasic nanocomposite platform for culturing chondrocytes. bioRxiv: 2019. doi:10.1101/790030. Preprint.

11. Collins JA, Wood ST, Bolduc JA, Nurmalasari NPD*, Chubinskaya S, Poole LB, Furdui CM, Nelson KJ, Loeser RF. Differential Peroxiredoxin Hyperoxidation Regulates MAP Kinase Signaling in Human Articular Chondrocytes. Free Radical Biology and Medicine: 2019; 134:139-152. doi:10.1016/j.freeradbiomed.2019.01.005.

10. Nelson KJ, Bolduc J, Wu H, Collins JA, Burke EA, Reisz JA, Klomsiri C, Wood ST, Yammani RR, Poole LB, Furdui CM, Loeser RF. H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes. The Journal of Biological Chemistry: 2018. 19;293(42):16376-16389. doi:10.1074/jbc.RA118.004613.

9. Meyerink J, Kota D*, Wood ST, Crawford GA. Transparent Titanium Dioxide Nanotubes: Processing, Characterization, and Application in Establishing Cellular Response Mechanisms. Acta Biomaterialia: 2018. 79:364-374. doi:10.1016/j.actbio.2018.08.039.

8. Collins JA, Wood ST, Nelson KJ, Rowe MA, Carlson CS, Chubinskaya S, Poole LB, Furdui CM, Loeser RF. Mitochondrial Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-Survival Signaling in Aging Chondrocytes. The Journal of Biological Chemistry: 2016. 291(13):6641-54. doi:10.1074/jbc.M115.693523.

7. Wood ST, Long DL, Reisz JA, Yammani RR, Burke EA, Klomsiri C, Poole LB, Furdui CM, Loeser RF. Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated with Fibronectin Fragments. Arthritis & Rheumatology: 2016. 68(1):117. doi:10.1002/art.39326. Featured article.

6. Patel AL, Chen X, Wood ST, Stuart ES, Arcaro KF, Molina DP, Petrovic S, Furdui CM, Tsang AW. Activation of Epidermal Growth Factor Receptor Is Required for Chlamydia Trachomatis Development. BMC Microbiology: 2014. 14(1):277. doi:10.1186/s12866-014-0277-4.

5. Wood ST, Dean BC, Dean D. A Computational Approach to Understand Phenotypic Structure and Constitutive Mechanics Relationships of Single Cells. Annals of Biomedical Engineering: 2013. 41(3):630. doi:10.1007/s10439-012-0690-5. Cover article.

4. Wood ST, Dean BC, Dean D. A linear programming approach to reconstructing subcellular structures from confocal images for automated generation of representative 3D cellular models. Medical Image Analysis: 2013. 17(3):337. doi:10.1016/j.media.2012.12.002.

3. Owczarczak AB, Shuford SO, Wood ST, Deitch S, Dean D. Creating Transient Cell Membrane Pores Using a Standard Inkjet Printer. Journal of Visualized Experiments: 2012. (61):3681. doi:10.3791/3681. Named to "JoVE's Top-10" most viewed articles.

2. Hemmer JD, Nagatomi J, Wood ST, Vertegel AA, Dean D, LaBerge M. Role of Cytoskeletal Components in Stress Relaxation Behavior of Adherent Vascular Smooth Muscle Cells. Journal of Biomechanical Engineering. Transactions of the ASME: 2009. 131(4):041001. doi:10.1115/1.3049860.

1. Markov DA, Dotson S, Wood S, Bornhop DJ. Non-Invasive Fluid Flow Measurements in Microfluidic Channels with Backscatter Interferometry. Electrophoresis: 2004. 25(21-22):3805. doi:10.1002/elps.200406139.


*Directly Supervised Graduate Student
Directly Supervised Undergraduate Student


Conference Publications

41. Meyerink J, Wood S, Mercuri J, Anderson R, Scott B, Crawford G. Application of Titanium Dioxide Nanotubes and Lattice Light-Sheet Microscopy in Establishing Early-Stage Cellular Response Mechanisms. The Minerals, Metals & Materials Society (TMS), 2020 Annual Meeting, San Diego, CA.

40. Haugen A*, Loyd Y, Kota D, Wood S. Quantification of Actin Motion in Chondrocytes Using Lattice Light-Sheet Microscopy. Biomedical Engineering Society (BMES), 2019 Annual Meeting, Philadelphia, PA.

39. Perez EC*, Saraswat R, Ratnayake I, Ahrenkiel SP, Wood S. Characterization and Optimization of Embedded Electrospun Nanofibers for the CellWell™. 2019 South Dakota Undergraduate Summer Research Symposium, Sioux Falls, SD.

38. Haugen A*, Loyd Y, Kota D, Wood S. Quantification of Actin Motion in Chondrocytes Using Lattice Light-Sheet Microscopy. 2019 South Dakota Undergraduate Summer Research Symposium, Sioux Falls, SD.

37. Saraswat R, Schutz W*, Ratnayake I, Zhu Z, Ahrenkiel SP, Wood S. Development of the CellWell™ - a novel micropatterned biphasic nanocomposite platform for chondrocyte cell culture. Society for Biomaterials (SFB), 2019 Annual Meeting, Seattle, WA. Poster presentation; winner of Engineering Cells and Their Microenvironments Student Poster Award.

36. Meyerink J, Kota D, Scott B, Anderson R, Wood S, Crawford G. Transparent Titanium Dioxide Nanotubes: Processing, Characterization, and Application in Establishing Cellular Response Mechanisms. The Minerals, Metals & Materials Society (TMS), 2019 Annual Meeting, San Antonio, TX.

35. Diaz D*, Meyerink J, Scott B, Anderson R, Wood S, Crawford G. Lattice Light Sheet Microscopy Imaging of Cell Adhesion Proteins on Transparent Titanium Dioxide Nanotubes. Biomedical Engineering Society (BMES), 2018 Annual Meeting, Atlanta, GA. Undergraduate Research & Design Track.

34. Saraswat R, Schutz W*, Zhu Z, Ahrenkiel SP, Wood S. Development of the CellWell™ - a novel micropatterned platform for cell culture and imaging. 2018 South Dakota Biotech Summit, Sioux Falls, SD. Invited poster due to noted commercialization potential of USD Biomaterials Day poster below.

33. Saraswat R, Schutz W*, Zhu Z, Ahrenkiel SP, Wood S. Development of the CellWell™ - a novel micropatterned platform for cell culture and imaging. University of South Dakota, 2018 Biomaterials Day, Sioux Falls, SD. First Place in student poster competition.

32. Feiner J*, Kota D, Wood S. Application of Mechanical Force to Chondrocytes. 2018 South Dakota Undergraduate Summer Research Symposium, Pierre, SD.

31. Schutz W*, Saraswat R, Ahrenkiel SP, Wood S. Synthesis of a Biphasic Micropatterned Well Array. 2018 South Dakota Undergraduate Summer Research Symposium, Pierre, SD.

30. Diaz D*, Meyerink J, Scott B, Anderson R, Wood S, Crawford G. Lattice Light Sheet Microscopy Imaging of Cell Adhesion Proteins on Transparent Titanium Dioxide Nanotubes. 2018 South Dakota Undergraduate Summer Research Symposium, Pierre, SD.

29. Saraswat R, Ryther T, Zhu Z, Wood S. Toward Development of the CellWell™ - A Novel Micropatterned Semi-3D Cell Culture Scaffold. Society for Biomaterials (SFB), 2018 Annual Meeting, Atlanta, GA.

28. Saraswat R, Ryther T, Zhu Z, Wood S. Characterization of Hydrogel Material Properties for the Development of the CellWell™ 2.5D Cell Culture and Imaging Platform. South Dakota School of Mines and Technology 2018 Nano Expo, Rapid City, SD.

27. Ryther T, Saraswat R, Zhu Z, Wood S. Toward development of the CellWell™ - Micropatterning Techniques for Shaping Hydrogels. South Dakota School of Mines and Technology 2018 Nano Expo, Rapid City, SD.

26. Saraswat R, Ryther T, Wood S. Characterization of hydrogel material properties for the development of the CellWell™ 2.5D cell culture and imaging platform. South Dakota School of Mines and Technology 2018 Student Research Symposium, Rapid City, SD.

25. Collins J, DeFoor M, Diekman B, Wood S, Bolduc J, Nelson K, Chubinskaya S, Poole L, Furdui C, Loeser R. Oxidative Stress-Induced Sulfenylation of Sirt6 is Associated with Enhanced NF-κB Signaling in Human Chondrocytes. Orthopaedic Research Society (ORS), 2018 Annual Meeting, New Orleans, LA.

24. Meyerink J, Kota D, Wood S, Crawford G. Transparent Titanium Dioxide Nanotubes: Processing, Characterization, and Application in Establishing Cellular Response Mechanisms. The Minerals, Metals & Materials Society (TMS), 2018 Annual Meeting, Phoenix, AZ.Meyerink J, Kota D, Wood S, Crawford G. Transparent Titanium Dioxide Nanotubes: Processing, Characterization, and Application in Establishing Cellular Response Mechanisms. 2017 SD EPSCoR All Investigators Meeting, Oacoma, SD.

23. Meyerink J, Kota D, Wood S, Crawford G. Transparent Titanium Dioxide Nanotubes: Processing, Characterization, and Application in Establishing Cellular Response Mechanisms. University of South Dakota, 2017 Biomaterials Day, Sioux Falls, SD.

22. Brett J*, Smith S, Wood S. Application of Mechanical Force to Chondrocytes via Magnetic Gradients. 2017 South Dakota Undergraduate Summer Research Symposium, Pierre, SD.

21. Dekle R*, Yang H, Ahrenkiel SP, Wood S. Toward the Development of the CellWell™ Semi-3D Cell Culture Platform. 2017 South Dakota Undergraduate Summer Research Symposium, Pierre, SD.

20. Collins J, Wood S, Poole L, Furdui C, Nelson K, Loeser R. Differential Peroxiredoxin Hyperoxidation Regulates Map Kinase Signaling in Human Articular Chondrocytes. Osteoarthritis Research Society International (OARSI), 2017 Annual Meeting, Las Vegas, NV.

19. Loeser R, Collins J, Nelson K, Wood S, Bolduc J, Poole L, Furdui C. Redox Regulation of c-jun N-terminal Kinase (JNK) Signaling in Articular Chondrocytes. Orthopaedic Research Society (ORS), 2017 Annual Meeting, San Diego, CA.

18. Collins J, Wood S, Poole L, Furdui C, Nelson K, Loeser R. The Level of Reactive Oxygen Species Differentially Regulates Peroxiredoxin Oxidation and Mitogen-Activated Protein Kinase Signaling In Human Chondrocytes. Osteoarthritis Research Society International (OARSI), 2016 Annual Meeting, Amsterdam, Kingdom of the Netherlands.

17. Wood S, Long D, Reisz J, Yammani R, Burke E, Klomsiri K, Poole L, Furdui C, Loeser R. Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated with Fibronectin Fragments. Osteoarthritis Research Society International (OARSI), 2015 Annual Meeting, Seattle, WA.

16. Wood S, Collins J, Long D, Reisz J, Poole L, Furdui C, Loeser R. Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes: Potential Role in Osteoarthritis. Gordon Research Conference, 2015 Redox Biology of Age-Related Diseases, Ventura, CA (Non-Presenting Author).

15. Loeser R, Wood S, Reisz J, Yammani R, Klomsiri K, Poole L, Furdui C. Redox Regulation of Cell Signaling in Chondrocytes Stimulated with Fibronectin Fragments. Orthopaedic Research Society (ORS), 2014 Annual Meeting, New Orleans, LA.

14. Wood S, Long D, Klomsiri C, Poole L, Furdui C, Loeser F., Redox Regulation of Cell Signaling in Chondrocytes Stimulated with Fibronectin Fragments. North Carolina Cartilage-Arthritis Research Alliance 2013 Annual Meeting, Winston-Salem, NC.

13. Wood S, Dean B, Kanetkar S, Dean D. Structural Modeling of Vascular Smooth Muscle Cell Mechanics Using Marc. MSC.Software, MSC Software 2011 Users Conference, Costa Mesa, CA.

12. Wood S, Deitch S, Dean D. Concurrent Visualization and Characterization of Single Cell Mechanical Properties. Society for Biomaterials (SFB), 2011 Annual Meeting, Orlando, FL.

11. Wood S, Dean B, Dean D. Computational Approaches to Understand Phenotypic Structure and Constitutive Mechanics Relationships of Single Cells. Life Sciences SCBIO-SCMedTech 2011 Annual Meeting, Charleston, SC.

10. Wood S, Dean B, Kanetkar S, Dean D. Structural Modeling of Vascular Smooth Muscle Cell Mechanics Using MSC Marc. Society for Biomaterials (SFB), 2011 Clemson University Biomaterials Day, Clemson, SC.

9. Shuford S, Owczarczak A, Wood S, Dean D. Incorporation of Fluorescent Actin Monomers in Living Cells using Inkjet Printing for Cellular Biomechanics Studies. Biomedical Engineering Society (BMES), 2011 Annual Meeting, Hartford, CT.

8. Wood S, Dean B, Dean D. Toward a Representative Phenotypic Representation of Structural Components of Vascular Smooth Muscle Cells. INBRE, 2011 Southeast Regional IDeA Meeting, New Orleans, LA.

7. Wood S, Dean B, Dean D. Toward a Representative Phenotypic Representation of Vascular Smooth Muscle Cells in Finite Element Analysis. Biomedical Engineering Society (BMES), 2010 Annual Meeting, Austin, TX.

6. Wood S, Dean B, Dean D. Toward a Representative Phenotypic Representation of Structural Components of Vascular Smooth Muscle Cells. Society for Biomaterials (SFB), 2010 Annual Meeting, Seattle, WA.

5. Wood S, Hemmer J, Dean B, Dean D. Structural Modeling of Vascular Smooth Muscle Cell Mechanics. Biomedical Engineering Society (BMES), 2009 Annual Meeting, Pittsburgh, PA.

4. Wood S, Hemmer J, Dean D. Hertzian Modeling of Vascular Smooth Muscle Cell Mechanics: A Simplified Preliminary Study of Contractile and Synthetic Phenotypes. SC Bioengineering Symposium, 2009 Annual Meeting, Columbia, SC.

3. Hemmer J, Wood S, Nagatomi J, Dean D, Wright-Walker C, LaBerge M. Effects of OxLDL on the Viscoelastic Properties of Vascular Smooth Muscle Cells. Society for Biomaterials (SFB), 2009 Annual Meeting, San Antonio, TX.

2. Wood S, Hemmer J, Dean B, Dean D. Quantifying Vascular Smooth Muscle Cell Cytoskeletal Structure. Biomedical Engineering Society (BMES), 2008 Annual Meeting, St. Louis, MO.

1. Wood S , Hemmer J, Dean D. Modeling of Vascular Smooth Muscle Cell Mechanics. Materials Research Society (MRS), 2008 Annual Meeting, San Francisco, CA.


*Undergraduate Student


Technical Publications

Wood S. Ground breaking cellular research: Intriguing study on cellular mechanic properties. Simulating Reality magazine: Winter 2012. MSC Software Corporation: Santa Ana, CA. p. 38.


Patents

Wood, S. inventor; South Dakota Board of Regents, assignee. Micropatterned Hydrogel for Cell Cultures. United States Provisional Patent Application No. 62828857. 2019, Apr 3. (Disclosed 2019, Jan 31.)